Amazing Applications for Microplates
Dr. Gyula Takatsy is credited for invention of the microplate in 1951 as a means to increase throughput and reduce the material requirements for running influenza detection assays. Since then, microplates have been considered a first step in automating various process. If you can get it to work in a test tube, chances are very good that you can increase productivity by employing microplate technology. Beyond just holding liquids, solids, and cells, some very clever applications* have been adapted to the microplate array format, as you'll discover in the examples below.
Amplifiers – enhanced absorbance: http://infoscience.epfl.ch/record/196423/files/2014_Suarez_Absorbance_BiosensBioelectron_198.pdf
Aquariums – zebrafish: http://www.viewpoint.fr/en/p/equipment/sideview-microplates
Circuit boards – chips: http://www.biophysics.com/cultureware.php
Crystal incubators – proteins: http://csmedia2.corning.com/LifeSciences/media/pdf/96%20well%20CrystalEX%20paper.pdf
Flower pots – Arabidopsis: http://www.jove.com/video/3280/ice-cap-method-for-growing-arabidopsis-tomato-plants-96-well-plates
Hot tubs – PCR cycling: http://www.bio-rad.com/en-us/category/96-well-plates-for-pcr
Metabolic chambers – H ion and O2 levels: http://www.seahorsebio.com/products/how-xf-works.php
Photo bombs – scintillation: http://www.perkinelmer.com/pages/020/staticpages/flashplates/default.xhtml
Pulverizers – plant and seed mills using ball bearings: http://opsdiagnostics.com/products/homogenizers/gg2010.htm
Shock therapy - capillary electrophoresis: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC19311/
Tissue traps – spheroids: http://www.perkinelmer.com/catalog/product/id/isp-06-010
Watering Holes – cell perfusion: http://pubs.rsc.org/en/content/articlelanding/2013/lc/c2lc41102d#!divAbstract
Water pistols – liquid transfers: http://www.labcyte.com/echo-technology/
Water parks – microchannels: http://siloambio.com/optimiser_platform_technology/
Ideas and Innovations
Do you have a favorite microplate design that was not mentioned here? Send me your suggestions and I will consider a “Daughter of Amazing Microplates” blog!
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*No endorsement intended or implied. (Okay, except for maybe the Seahorse one!)